Medical Researches
Moderately Effective
Based on 44 Researches
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
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Synbiotics improve rheumatoid arthritis symptomsSynbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial.
High relevance; significant findings
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
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We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
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We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
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LC-STH-13 counters lupus effects LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway.
High relevance, promising findings
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
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User Reviews
These probiotics helped restore my son's appetite and regular stool. Previously, he struggled with eating and scheduled bathroom visits due to an autoimmune disorder. After just two weeks, we noticed significant changes; he now enjoys food without issues.
I have used these probiotics thrice for my child, who suffered from severe dysbiosis due to an autoimmune disorder. After just two days of using these probiotics, his condition improved remarkably compared to previous treatments. I recommend them for both prevention and recovery.
Effective formula observed
I loved these organic probiotics; they worked remarkably well. My child's gastrointestinal function returned to normal within days. I ordered two more cans as I believe good gut health is vital for immunity.
I appreciated the effect of these probiotics after antibiotics. My daughter, aged 4, experienced severe stool issues after medication. However, since taking this probiotic, we normalised her stool within a short time. I'm ordering a second pack for her ongoing autoimmune disorder treatment.
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Effective stool regulation
These probiotics are fantastic! My child had severe toilet issues despite trying many options. After one week of using these, everything improved significantly, resolving the problem with his autoimmune disorder.